Denavir and breast feeding

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Penciclovir is used on the lips and faces of adults to treat cold sores caused by herpes simplex virus. Penciclovir does not cure herpes infections but decreases pain and itching if applied when the earliest symptoms first appear. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. Penciclovir comes as a cream. It is usually used externally every 2 hours while you are awake for 4 days. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist or doctor to explain any part you do not understand.
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Denavir Cream

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Denavir (penciclovir cream, 1%)

A synthetic acyclic guanine derivative with antiviral activity, mainly used to treat infections from herpes simplex virus HSV types 1 and 2. In HSV infected cells, penciclovir is phosphorylated by viral thymidine kinase and subsequently converted by cellular kinases into the active metabolite, penciclovir triphosphate, which competitively inhibits viral HSV polymerase by blocking deoxyguanosine triphosphate substrate binding. As a result, herpes viral DNA synthesis and replication are selectively inhibited. Only water-miscible cream or gel products should be applied to the breast because ointments may expose the infant to high levels of mineral paraffins via licking. Exposure of babies to C 15 -C 45 mineral paraffins from human milk and breast salves. Regul Toxicol Pharmacol. PMID:
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Penciclovir

NCBI Bookshelf. Although there is no published experience with penciclovir during breastfeeding, infant side effects are unlikely with maternal topical application to small areas of the mother's body away from the breast. Only water-miscible cream or gel products should be applied to the breast because ointments may expose the infant to high levels of mineral paraffins via licking. Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation.
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Not all drugs are present in clinically significant amounts in human milk or pose a risk to the infant. Certain classes of drugs can be problematic, either because of accumulation in breast milk or due to their effects on the nursing infant or mother. Vaccines recommended for the mother during the postpartum period are designed to protect the infant and the lactating mother. Even though most drugs and therapeutics are safe for breastfeeding mothers and infants, the AAP advises all physicians to obtain the most up-to-date information on drugs and lactation. You may be trying to access this site from a secured browser on the server.
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